Work

Cg Cmk1 Activates Cg Rds2 To Resist Low-pH Stress in Candida glabrata

Year: 2020

Type: article

Abstract: An acidic environment is the main problem in the production of organic acids in C. glabrata . The present study reports that the calcium/calmodulin-dependent protein kinase Cg Cmk1 positively regulates Cg Rds2 to increase intracellular ATP content, membrane permeability, and resistance to low-pH stress. Hence, the transcription factor Cg Rds2 may be a potential target for improving the acid stress tolerance of C. glabrata during the fermentation of organic acids. The present study also establishes a new link between the calcium signaling pathway and energy metabolism.

Source: Applied and Environmental Microbiology

DOI: 10.1128/aem.00302-20

Authors: Chengjin Wu, Guoxing Zhu, Qiang Ding, Pei Zhou, Liming Liu, Xiulai Chen

Institutions: Jiangnan University, State Key Laboratory of Food Science and Technology

Language: English

Topic: Fungal and yeast genetics research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Natural Science Foundation of China

Awards: G1482514219, 苹果酸合成路径的碳流封存调控及其机制解析