Restarted primal–dual Newton conjugate gradient method for enhanced spatial resolution of reconstructed cone-beam x-ray luminescence computed tomography images
Year: 2020
Type: article
Abstract: Cone-beam x-ray luminescence computed tomography (CB-XLCT) has been proposed as a promising imaging tool, which enables three-dimensional imaging of the distribution of nanophosphors (NPs) in small animals. However, the reconstruction performance is usually unsatisfactory in terms of spatial resolution due to the ill-posedness of the CB-XLCT inverse problem. To alleviate this problem and to achieve high spatial resolution, a reconstruction method consisting of inner and outer iterations based on a restarted strategy is proposed. In this method, the primal-dual Newton conjugate gradient method (pdNCG) is adopted in the inner iterations to get fast reconstruction, which is used for resetting the permission region and increasing the convergence speed of the outer iteration. To assess the performance of the method, both numerical simulation and physical phantom experiments were conducted with a CB-XLCT system. The results demonstrate that compared with conventional reconstruction methods, the proposed re-pdNCG method can accurately and efficiently resolve the adjacent NPs with the least relative error.
Source: Physics in Medicine and Biology
Authors: Peng Gao, Kai Cheng, Emil Schüler, Mengyu Jia, Wei Zhao, Lei Xing
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Cancer Institute
OpenAlex ID: W3014661106