Work

Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes

Year: 2020

Type: article

Abstract: Key Points Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow aplasia, without a known etiologic trigger. Clonal expansion of CD8+ effector T lymphocytes can occur following vaccination and accompany graft dysfunction or aplastic anemia relapse.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2019000853

Authors: Caitlin Ritz, Wenzhao Meng, Natasha L. Stanley, Miren L. Baroja, Chong Xu, Patrick Yan, Alexander C. Huang, Ryan Hausler, Peter Nicholas, Jian-Meng Fan, David Lieberman, Beatriz M. Carreno, Eline T. Luning Prak, Timothy S. Olson, Daria V. Babushok

Institutions: Children's Hospital of Philadelphia, Hospital of the University of Pennsylvania, Parker Institute for Cancer Immunotherapy, University of Pennsylvania

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800

Funders: U.S. Department of Defense, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: Early Clonal Evolution in Acquired Aplastic Anemia, G5363075674

OpenAlex ID: W3014960621

FWCI: 2.479

Cites: 25

Cited by: 23

Related to: 10