Work

ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.

Year: 2020

Type: article

Abstract: and triggered apoptotic osteosarcoma cell death. ROCK2 inhibited the TRAIL-mediated apoptotic pathway in osteosarcoma cells and promoted activation. Mechanistically, ROCK2 affected osteosarcoma progression and TRAIL resistance by modifying O-GlcNAcylation through O-GlcNAc transferase degradation. Taken together, our results demonstrated a unique mechanism whereby ROCK2 influences osteosarcoma progression and TRAIL resistance, hence improving osteosarcoma management.

Source: PubMed Central

Authors: Xueqiang Deng, Xuan Yi, Da Huang, Peng Liu, Leifeng Chen, Yunyan Du, Liang Hao

Institutions: Second Affiliated Hospital of Nanchang University, Third Affiliated Hospital of Nanchang University, Third Hospital of Nanchang, Nanchang University, Jiangxi Provincial People's Hospital

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3014993061

FWCI: 1.288

Cites: 33

Cited by: 21

Related to: 10