Work

Role of the ESCRT Pathway in Laccase Trafficking and Virulence of Cryptococcus neoformans

Year: 2020

Type: article

Abstract: The endosomal sorting complex required for transport (ESCRT) plays a crucial role in the transportation and degradation of proteins. We determined that Vps27, a key protein of the ESCRT-0 complex, is required for the transport of the virulence factor laccase to the cell wall in Cryptococcus neoformans . Laccase activity was perturbed, as was melanin production, in vps27 Δ strains. In the absence of VPS27 , there was an accumulation of multivesicular bodies with vacuolar fragmentation and mistargeting of the vacuolar carboxypeptidase CPY/Prc1, resulting in an extracellular localization.

Source: Infection and Immunity

DOI: 10.1128/iai.00954-19

Authors: Yoon-Dong Park, Shu Hui Chen, Emma Camacho, Arturo Casadevall, Peter R. Williamson

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Johns Hopkins University

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases