Effects of sedentary behaviour interventions on biomarkers of cardiometabolic risk in adults: systematic review with meta-analyses
Year: 2020
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: CONTEXT/PURPOSE: Observational and acute laboratory intervention research has shown that excessive sedentary time is associated adversely with cardiometabolic biomarkers. This systematic review with meta-analyses synthesises results from free living interventions targeting reductions in sedentary behaviour alone or combined with increases in physical activity. METHODS: Six electronic databases were searched up to August 2019 for sedentary behaviour interventions in adults lasting for ≥7 days publishing cardiometabolic biomarker outcomes covering body anthropometry, blood pressure, glucose and lipid metabolism, and inflammation (54 studies). The pooled effectiveness of intervention net of control on 15 biomarker outcomes was evaluated using random effects meta-analyses in the studies with control groups not providing other relevant interventions (33 studies; 6-25 interventions analysed). RESULTS: =0.0-72.9). CONCLUSIONS: Our review of interventions targeting sedentary behaviour reductions alone, or combined with increases in physical activity, found evidence of effectiveness for improving some cardiometabolic risk biomarkers to a small degree. There was insufficient evidence to evaluate inflammation or vascular function. Key limitations to the underlying evidence base include a paucity of high-quality studies, interventions lasting for ≥12 months, sensitive biomarkers and clinical study populations (eg, type 2 diabetes). PROSPERO TRIAL REGISTRATION NUMBER: CRD42016041742.
Institutions: Baker Heart and Diabetes Institute, The University of Queensland, Swinburne University of Technology, The Alfred Hospital, Deakin University, The University of Western Australia, Monash University, Australian Catholic University, Curtin University, University of Cambridge, MRC Epidemiology Unit
Language: English
Topic: Physical Activity and Health
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Too much sitting and too little exercise: changing environments to help Australians sit less, move more and improve their health, Reducing prolonged sitting time in adults, G2892497062, Moving More and Sitting Less: Evidence to Inform the Prevention and Management of Type 2 Diabetes, G5591412214, Physical activity epidemiology, Unlocking the health effects of sitting to reduce chronic disease
OpenAlex ID: W3015688288