Work

Structural Basis of Reduced Susceptibility to Ceftazidime-Avibactam and Cefiderocol in Enterobacter cloacae Due to AmpC R2 Loop Deletion

Year: 2020

Type: article

Abstract: Ceftazidime-avibactam and cefiderocol are two of the latest generation β-lactam agents that possess expanded activity against highly drug-resistant bacteria, including carbapenem-resistant Enterobacterales . Here, we show that structural changes in AmpC β-lactamases can confer reduced susceptibility to both agents. A multidrug-resistant Enterobacter cloacae clinical strain (Ent385) was found to be resistant to ceftazidime-avibactam and cefiderocol without prior exposure to either agent.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00198-20

Authors: Akito Kawai, Christi L. McElheny, Alina Iovleva, Ellen G. Kline, Nicolas Sluis-Cremer, Ryan K. Shields, Yohei Doi

Institutions: Fujita Health University, University of Pittsburgh

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasis, Use of site-specific pharmacokinetics to optimize antibiotic combinations and prevent the emergence of resistance against CRE, Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP), Mechanisms of cefiderocol resistance, Colistin resistance in extensively drug-resistant Gram-negative pathogens, Characterization and suppression of resistance to new CRE agents

OpenAlex ID: W3015842467

FWCI: 4.008

Cites: 38

Cited by: 84

Related to: 10