Work

Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study

Year: 2020

Type: article

Study design: Observational Study

Abstract: ABSTRACT We previously investigated the association between five ‘first-generation’ measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study. The present study assesses cancer risk associations for three recently developed methylation-based measures of aging: PhenoAge, GrimAge , and predicted telomere length. We estimated rate ratios (RRs) for risk of colorectal (N=814), gastric (N=166), kidney (N=139), lung (N=327), mature B-cell (N=426), prostate (N=847) and urothelial (N=404) cancer, using conditional logistic regression models. We observed relatively strong associations of PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers (RR per standard deviation ∼ 1.2-1.3). Similar findings were obtained for GrimAge , but the association with lung cancer risk was remarkably stronger (RR ∼ 1.8 after adjustment for smoking status, pack-years, starting age, time since quitting and other cancer risk factors). The methylation-based measures PhenoAge and GrimAge may provide insights into the relationship between biological aging and cancer.

Source: JNCI Cancer Spectrum

DOI: 10.1093/jncics/pkaa109

Authors: Pierre-Antoine Dugué, Julie K Bassett, Ee Ming Wong, JiHoon E Joo, Shuai Li, Chenglong Yu, Daniel F Schmidt, Enes Makalic, Nicole Wong Doo, Daniel D Buchanan, Allison M Hodge, Dallas R English, John L Hopper, Graham G Giles, Melissa C Southey, Roger L Milne

Institutions: The University of Melbourne, Cancer Council Victoria, Monash Health, Monash University, University of Cambridge, The University of Sydney, The Royal Melbourne Hospital, Victorian Comprehensive Cancer Centre

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,050

Funders: Monash University, Medical Research Council, National Health and Medical Research Council, Cancer Council Victoria

Awards: G1094733267, Personalized clinical genomics and epigenomics., Methylation of DNA and colorectal cancer, Methylation as a risk and prognostic factor for breast cancer, G3729156826, G5616697689, Methylation and the risk of urothelial cell cancer, Epidemiology of Chronic Disease, Health Interventions and DNA Studies, G7199237069, Precision Public Health for major cancers - novel approaches to building the genetic, epigenetic and lifestyle knowledge base for assessing risk and prognosis, Methylation as a risk factor for prostate cancer., Novel molecular markers of lung cancer risk and survival, G8123808567, Risk and prognostic factors for breast cancer of different immunohistochemical subtypes, G8797697851, Increasing precision in epidemiological exposure assessment by integrating genetic and epigenetic data

OpenAlex ID: W3100302089

FWCI: 3.204

Cites: 39

Cited by: 92

Related to: 10