Work

The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site

Year: 2020

Type: article

Abstract: This study by Tóth et al. has defined that the N-terminal MHR1/2 domain is a conserved ADPR binding site in TRPM2 from ancient cnidarians to vertebrate, and that it is the key ligand binding site for invertebrate TRPM2 channel activation by ADPR, the same as observed in human and zebrafish TRPM2.

Source: The Journal of General Physiology

DOI: 10.1085/jgp.201912555

Authors: Wei Lü, Juan Du

Institution: Van Andel Institute

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke

Awards: Structural and functional studies of the human TRPM4 and TRPM5 channels, G2524023423, G657293316, G9000093320