Chalcomoracin prevents vitreous‐induced activation of AKT and migration of retinal pigment epithelial cells
Year: 2021
Type: article
Abstract: Retinal pigment epithelial (RPE) cells are the major cell type in the epi- or sub-retinal membranes in the pathogenesis of proliferative vitreoretinopathy (PVR), which is a blinding fibrotic eye disease and still short of effective medicine. The purpose of this study is to demonstrate whether Chalocomoracin (CMR), a novel purified compound from fungus-infected mulberry leaves, is able to inhibit vitreous-induced signalling events and cellular responses intrinsic to PVR. Our studies have revealed that the CMR IC50 for ARPE-19 cells is 35.5 μmol/L at 72 hours, and that 5 μmol/L CMR inhibits vitreous-induced Akt activation and p53 suppression; in addition, we have discovered that this chemical effectively blocks vitreous-stimulated proliferation, migration and contraction of ARPE-19 cells, suggesting that CMR is a promising PVR prophylactic.
DOI: 10.1111/jcmm.16590
Authors: Haote Han, Yanhui Yang, Bing Liu, Jingkui Tian, Lijun Dong, Hui Qi, Wei Zhu, Jiantao Wang, Hetian Lei
Institutions: Massachusetts Eye and Ear Infirmary, Harvard University, Chinese Academy of Sciences, Zhejiang Cancer Hospital, University of Chinese Academy of Sciences, Zhejiang University, Ningxia Medical University, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Jinan University
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,388
OpenAlex ID: W3195993618