Work

The pathological role of ferroptosis in ischemia/reperfusion-related injury

Year: 2020

Type: article

Abstract: Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many I/R models. In this review, we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role that ferroptosis plays in I/R, providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury (IRI) associated cell damage and death.

Source: 动物学研究

DOI: 10.24272/j.issn.2095-8137.2020.042

Authors: Hong-Fa Yan, Qing-Zhang Tuo, Qiao-Zhi Yin, Peng Lei

Institutions: Sichuan University, West China Hospital of Sichuan University, State Key Laboratory of Biotherapy, Chengdu University of Traditional Chinese Medicine

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation