Year: 2020
Type: article
Abstract: Fractional flow reserve is the current invasive gold standard for assessing the ischemic potential of an angiographically intermediate coronary stenosis. Procedural cost and time, the need for coronary vessel instrumentation, and the need to administer adenosine to achieve maximal hyperemia remain integral components of invasive fractional flow reserve. The number of new alternatives to fractional flow reserve has proliferated over the last ten years using techniques ranging from alternative pressure wire metrics to anatomic simulation via angiography or intravascular imaging. This review article provides a critical description of the currently available or under-development alternatives to fractional flow reserve with a special focus on the available evidence, pros, and cons for each with a view towards their clinical application in the near future for the functional assessment of coronary artery disease.
Authors: Giovanni Luigi De Maria, Hector M. Garcia-Garcia, Roberto Scarsini, Alexandre Hideo-Kajita, Nieves Gonzalo López, Antonio Maria Leone, Giovanna Sarno, Joost Daemen, Evan Shlofmitz, Allen Jeremias, Matteo Tebaldi, Hiram Grando Bezerra, Shengxian Tu, Pedro A. Lemos, Yuichi Ozaki, Kazuhiro Dan, Carlos Collet, Adrian P. Banning, Emanuele Barbato, Nils P. Johnson, Ron Waksman
Institutions: John Radcliffe Hospital, Oxford University Hospitals NHS Trust, MedStar Washington Hospital Center, Washington Hospital, University of Oxford, Hospital Clínico San Carlos, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, Uppsala University, Erasmus University Rotterdam, St. Francis Hospital, University of Ferrara, University Hospitals of Cleveland, Shanghai Jiao Tong University, Universidade de São Paulo, Hospital Israelita Albert Einstein, Instituto do Coração - HCFMUSP, Onze Lieve Vrouwziekenhuis Hospital, Federico II University Hospital, University of Naples Federico II, Memorial Hermann, Memorial Hermann–Texas Medical Center, The University of Texas Health Science Center at Houston
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3016600599