Work

A plasmonic nanoledge array sensor for detection of anti-insulin antibodies of type 1 diabetes biomarker

Year: 2020

Type: article

Abstract: Here we present a plasmonic nanoledge device with high sensitivity and selectivity used to detect protein biomarkers simply by functionalizing the device, which specifically binds to particular biomolecule or biomarkers. We employ this plasmonic nanoledge device for the detection of anti-insulin antibodies of type 1 diabetes (T1D) in buffer and human serum at the range of pg ml −1 to 100 ng ml −1 . The signal transduction is based on the extraordinary optical transmission (EOT) through the nanoledge array and the optical spectral changes with the biological binding reaction between the surface functionalized insulin with anti-insulin antibody. Control experiments indicate little interferences from the human serum background and addition of other proteins such as bovine serum albumin (BSA) and epidermal growth factor (EGF) at 20 ng ml −1 . The high sensitivity, specificity and easy adaptability of the plasmonic device offer new opportunities in biosensing and diagnostic applications for T1D.

Source: Nanotechnology

DOI: 10.1088/1361-6528/ab8c05

Authors: Bhawna Bagra, Taylor Mabe, Frank Tukur, Jianjun Wei

Institution: University of North Carolina at Greensboro

Language: English

Topic: Plasmonic and Surface Plasmon Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green