Work

Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia

Year: 2020

Type: article

Abstract: Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of particular interest. Here, we show that mice heterozygous for Trim28, an essential epigenetic regulator, suffer gradual testicular degeneration. Contrary to previous reports we detect Trim28 expression in spermatogonia, albeit at low levels. Further reduction through Trim28 heterozygosity increases the propensity of SSCs to differentiate at the cost of self-renewal.

Source: Stem Cell Reports

DOI: 10.1016/j.stemcr.2020.03.013

Authors: Joel H.L. Tan, Heike Wollmann, Ans M.M. van Pelt, Philipp Kaldis, Daniel M. Messerschmidt

Institutions: Agency for Science, Technology and Research, National University of Singapore, Institute of Molecular and Cell Biology, Amsterdam UMC Location University of Amsterdam, University of Amsterdam

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800