Work

Mesenchymal Stem Cells Modifications for Enhanced Bone Targeting and Bone Regeneration

Year: 2020

Type: article

Abstract: In pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal stem cells (MSCs) give rise to the osteogenic lineage, a number of clinical trials investigated the potential of MSCs transplantation for bone regeneration. However, the engraftment of transplanted cells is often hindered by insufficient oxygen and nutrients supply and the tendency of MSCs to home to different sites of the body. In this review, we discuss various approaches of MSCs transplantation for bone regeneration including scaffold and hydrogel constructs, genetic modifications and surface engineering of the cell membrane aimed to improve homing and increase cell viability, proliferation and differentiation.

Source: Regenerative Medicine

DOI: 10.2217/rme-2019-0081

Authors: Yuliya Safarova, Bauyrzhan Umbayev, Gonzalo Hortelano, Sholpan Askarova

Institution: Nazarbayev University

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Ministry of Education and Science of the Republic of Kazakhstan, Nazarbayev University