Year: 2020
Type: article
Abstract: (Cell Reports 30, 4567–4583.e1–e5; March 31, 2020) The title in the originally published version of this paper had erroneous text (LIN28B Control of EWS-FLI1 Stability) appended to the end. The title has been corrected here and online. The publisher apologizes for this error. LIN28B Underlies the Pathogenesis of a Subclass of Ewing SarcomaKeskin et al.Cell ReportsMarch 31, 2020In BriefKeskin et al. show that Lin28B directly binds EWS-FLI-1 and maintains its stability in ~10% of Ewing sarcomas. Lin28B depletion or its chemical inhibition in these tumors results in the loss of EWS-FLI-1 expression and tumor deconstruction. Lin28B may provide an attractive therapeutic target in a subset of Ewing sarcomas. Full-Text PDF Open Access
Source: Cell Reports
Authors: Tugba Keskin, Arnaud Bakaric, Patricia Waszyk, Gaylor Boulay, Matteo Torsello, Sandrine Cornaz-Buros, Nadja Chevalier, Thibaud Geiser, Patricia Martin, Angela Volorio, Sowmya Iyer, Anupriya Kulkarni, Igor Letovanec, Stéphane Cherix, Gregory M. Cote, Edwin Choy, Antonia Digklia, Michael Montemurro, Ivan Chebib, Petur G. Nielsen, Angel M. Carcaboso, Jaume Mora, Raffaele Renella, Mario L. Suvà, Carlo Fusco, Paolo Provero, Miguel N. Rivera, Nicolò Riggi, Ivan Stamenkovic
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,200
OpenAlex ID: W3016977956