Work

The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs

Year: 2020

Type: review

Abstract: Glutamate (Glu) is the most abundant excitatory neurotransmitter in the central nervous system (CNS). HIV-1 and viral proteins compromise glutamate synaptic transmission, resulting in poor cell-to-cell signaling and bystander toxicity. In this study, we identified that myeloid HIV-1-brain reservoirs survive in Glu and glutamine (Gln) as a major source of energy. Thus, we found a link between synaptic compromise, metabolomics of viral reservoirs, and viral persistence. In the current manuscript we will discuss all these interactions and the potential to achieve eradication and cure using this unique metabolic profile.

Source: Frontiers in Cellular and Infection Microbiology

DOI: 10.3389/fcimb.2020.00261

Authors: Anna Maria Gorska, Eliseo A. Eugenin

Institution: The University of Texas Medical Branch at Galveston

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950