[Clinical effect of two different regimens in treatment of acute lymphoblastic leukemia children with bone marrow recurrence].
Year: 2020
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To study the short-term effect of two different re-induction regimens in the treatment of acute lymphoblastic leukemia (ALL) children with bone marrow recurrence. METHODS: A retrospective analysis was performed for 57 ALL children with bone marrow recurrence. According to their treatment regimen, they were divided into two groups: VMDP (vincristine + mitoxantrone + dexamethasone + PEG-asparaginase; n=42) and VIDP (vincristine + idarubicin + dexamethasone + PEG-asparaginase; n=15). The two groups were compared in terms of complete response rate and incidence rate of adverse reactions. RESULTS: There was no significant difference in complete response rate between the VMDP and VIDP groups (74% vs 73%, P>0.05). All children experienced grade ≥3 hematological adverse events. The VMDP group had a significantly lower chemotherapy-related mortality rate than the VIDP group (P<0.05). There was no significant difference in the incidence rate of infection between the two groups (P>0.05). CONCLUSIONS: For ALL children with bone marrow recurrence, both re-induction regimens can achieve a relatively high complete response rate, and VMDP regimen has a lower chemotherapy-related mortality rate and can thus be used as an option for re-induction in ALL children with bone marrow recurrence.
Source: PubMed Central
Authors: Bei-Bei Zhao, Xiao-Juan Chen, Ye Guo, Wen-Yu Yang, Yao Zou, Yu-Mei Chen, Li Zhang, Min Ruan, Xiao-Ming Liu, Fang Liu, Tian-Feng Liu, Ben-Quan Qi
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3017043621