Work

The bidirectional relationship between CFTR and lipids

Year: 2020

Type: review

Abstract: Cystic Fibrosis (CF) is the most common life-shortening genetic disease among Caucasians, resulting from mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). While work to understand this protein has resulted in new treatment strategies, it is important to emphasize that CFTR exists within a complex lipid bilayer - a concept largely overlooked when performing structural and functional studies. In this review we discuss cellular lipid imbalances in CF, mechanisms by which lipids affect membrane protein activity, and the specific impact of detergents and lipids on CFTR function.

Source: Communications Biology

DOI: 10.1038/s42003-020-0909-1

Authors: Kirsten A. Cottrill, Carlos M. Farinha, Nael A. McCarty

Institutions: Emory University, University of Lisbon, Children's Healthcare of Atlanta

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,290