The Utility of the National Alzheimer’s Coordinating Center’s Database for the Rapid Assessment of Evolving Neuropathologic Conditions
Year: 2020
Type: article
Abstract: The field of dementia research is rapidly evolving, especially with regards to our understanding of the diversity of neuropathologic changes that underlie cognitive decline. Definitions and criteria for known conditions are being periodically revised and refined, and new findings are being made about neuropathologic features associated with dementia status. The database maintained by the National Alzheimer's Coordinating Center (NACC) offer researchers a robust, rapid, and statistically well-powered method to evaluate the implications of newly identified neuropathologic conditions with regards to comorbidities, demographic associations, cognitive status, neuropsychologic tests, radiographic findings, and genetics. NACC data derive from dozens of excellent US Alzheimer disease research centers, which collectively follow thousands of research volunteers longitudinally. Many of the research participants are autopsied using state-of-the-art methods. In this article, we describe the NACC database and give examples of its use in evaluating recently revised neuropathologic diagnoses, including primary age-related tauopathy (PART), limbic predominant age-related TDP-43 encephalopathy (LATE), and the preclinical stage of Alzheimer disease neuropathologic change, based on the National Institute on Aging-Alzheimer's Association consensus guidelines. The dementia research community is encouraged to make use of this readily available database as new neuropathologic changes are recognized and defined in this rapidly evolving field.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1017046091, G1053905225, G117713310, G1228824270, Michigan Alzheimer's Disease Core Center, UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, G1602633198, G1711016037, G1859882300, G2190936067, G219693323, G2515091901, Neurobiology of Alzheimer's Disease and Aging, G2742075923, G2984989008, National Alzheimer's Coordinating Center, Alzheimer's Disease Research Center, Regulation of tau expression in Alzheimer disease and aging, G36881302, G384347443, G3919444319, G40706755, G4076092645, G4270810120, Alzheimer's Disease Core Center, Cleveland Alzheimer's Disease Research Center, The Alzheimer's Disease Research Center at the University of California, Irvine, G4417220376, Oregon Alzheimer's Disease Center, G5151170341, G556672640, G5977822913, G603598372, University of Kansas Alzheimer's Disease Core Centers, Alzheimer's Disease Research Center, Alzheimer Disease Research Center, Yale Alzheimer Disease Research Center, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, Boston University Alzheimer's Disease Center, Alzheimer's Disease Core Center, Emory Alzheimer's Disease Center, University of Florida - Mt. Sinai Medical Center AD Research Center, G816726602, G828200374, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Alzheimer's Disease Research Center, Wisconsin Alzheimer's Disease Research Center, University of Kentucky Alzheimer's Disease Research Center, Massachusetts Alzheimer's Disease Research Center (MADRC)
OpenAlex ID: W3017188906