Dimethyl Sulfoxide: A Central Player Since the Dawn of Cryobiology, is Efficacy Balanced by Toxicity?
Year: 2020
Type: review
Abstract: Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.
Source: Regenerative Medicine
Institutions: The Royal Free Hospital, University College London, National Academy of Sciences of Ukraine, Institute for Problems of Cryobiology and Cryomedicine, King's College London, Centre for Ultrastructural Imaging, Guy's Hospital, Cell and Gene Therapy Catapult, National Health Service, Royal Free London NHS Foundation Trust, University Hospital Hradec Králové, Czech Academy of Sciences, Institute of Experimental Medicine, Loughborough University, Chinese Academy of Sciences, Institute of Zoology
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W3018041402