Work

Dinaciclib prolongs survival in the LSL-KrasG12D/+ ; LSL-Trp53R172H/+ ; Pdx-1-Cre (KPC) transgenic murine models of pancreatic ductal adenocarcinoma.

Year: 2020

Type: article

Abstract: T cells were increased after dinaciclib treatment in KPC mice. Additionally, the mean apparent diffusion coefficient values of KPC tumor calculated from diffusion weighted MR images were significantly lower after dinaciclib treatment (P = 0.033). These finding suggest that dinaciclib as a single agent can inhibit tumor growth and improve the overall survival in KPC mice.

Source: PubMed Central

Authors: Jia Yang, Su Hu, Junjie Shangguan, Aydin Eresen, Yu Li, Quanhong Ma, Vahid Yaghmai, Al B Benson Iii, Zhuoli Zhang

Institutions: Northwestern University, First Affiliated Hospital of Soochow University, Affiliated Hospital of Qingdao University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Awards: Image-guided Interventional Combination Liver Cancer Immunotherapy, MRI-Guided Irreversible Electroporation Ablation for Liver Tumors, Developing MRI-Guided Preventive Dendritic Cell Vaccination Strategy to Avoid Post-surgical Pancreatic Cancer Recurrence and Metastasis

OpenAlex ID: W3018430814

FWCI: 0.542

Cites: 49

Cited by: 6

Related to: 10