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Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation

Year: 2020
Type: article
Abstract: (1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) with ApcMin/+ mice. (3) Results: The resulting Winnie-ApcMin/+ model combines an inflammatory background with a genetic predisposition to small intestinal polyposis. Winnie-ApcMin/+ mice show an early occurrence of inflammatory signs and dysplastic lesions in the distal colon with a specific molecular signature. (4) Conclusion: The Winnie-ApcMin/+ model is a perfect model to demonstrate that chronic inflammation represents a crucial risk factor for the onset and progression of tumoral lesions in individuals genetically predisposed to CRC.
DOI: 10.3390/ijms21082972
Authors: Stefania De Santis, Giulio Verna, Grazia Serino, Raffaele Armentano, Elisabetta Cavalcanti, Marina Liso, Manuela Dicarlo, Sergio Coletta, Mauro Mastronardi, Antonio Lippolis, Angela Tafaro, Angelo Santino, Aldo Pinto, Pietro Campiglia, Alex Y. Huang, Fabio Cominelli, Theresa T. Pizarro, Marcello Chieppa
Institutions: University of Salerno, University of Bari Aldo Moro, Gastroenterology Hospital "Saverio de Bellis", Institute of Sciences of Food Production, Case Western Reserve University, European Biomedical Research Institute of Salerno
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,112
Awards: G1464101492, G1713571305, G1888088267, G3770228856, G6690515076, G840316475, G993091243
OpenAlex ID: W3018535199
FWCI: 1.449
Cites: 28
Cited by: 14
Related to: 10