Current Perspectives on Coronavirus Disease 2019 and Cardiovascular Disease: A White Paper by the JAHA Editors
Year: 2020
Type: article
Abstract: Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has infected more than 3.0 million people worldwide and killed more than 200,000 as of April 27, 2020, making it the most lethal pandemic since the Spanish flu of 1918. 1, 2 COVID-19 may preferentially infect individuals with cardiovascular conditions, is more severe in subjects with cardiovascular comorbidities, may directly or indirectly affect the heart and may interact with cardiovascular medications.3 In addition, the widespread effects of the pandemic on the global healthcare system affects the routine and emergency cardiac care for patients who are, may be, or are not infected with COVID-19.In this White Paper authored by the Physicians and Scientists on the Editorial Board of the Journal of the American Heart Association (JAHA), we address the cardiovascular comorbidities of COVID-19 infection; the diagnosis and treatment of standard cardiovascular conditions during the pandemic; and the diagnosis and treatment of the cardiovascular consequences of COVID-19 infection.In addition, we will touch on the safety of healthcare workers and on ethical issues related to patient care in the COVID-19 era. COVID-19 disease and TroponinTake Home Points:• Elevated troponin levels are frequently seen in patients with COVID-19 disease; and are associated with increased severity of disease and risk of death.•In the absence of a specific etiology, elevated levels of troponins are likely due to myocardial injury from inflammation or a direct effect of SARS-CoV-2 infection.Research questions:• The role of troponin in clinical risk stratification, and as a prognostic factor of disease severity and mortality, needs to be further explored, particularly after accounting for other confounders.
Authors: Ajay K. Gupta, Hani Jneid, Daniel Addison, Hossein Ardehali, Amelia K. Boehme, Sanket Borgaonkar, Romain Boulestreau, Kevin Clerkin, Nicolas Delarche, Holli A. DeVon, Isabella M. Grumbach, Jose Gutierrez, Daniel A. Jones, Vikas Kapil, Carmela Maniero, Amgad Mentias, Pamela S. Miller, Sher May Ng, Jai D. Parekh, Reynaldo H. Sanchez, Konrad Teodor Sawicki, Anneline S. J. M. te Riele, Carol Ann Remme, Barry London
Institutions: St Bartholomew's Hospital, Queen Mary University of London, Barts Health NHS Trust, William Harvey Research Institute, Baylor College of Medicine, The Ohio State University, Northwestern University, Columbia University, Centre Hospitalier De Pau, Columbia University Irving Medical Center, University of California, Los Angeles, University of Iowa, University of Iowa Health Care, University of London, UCLA Health, Utrecht University, University Medical Center Utrecht, Amsterdam UMC Location University of Amsterdam, Amsterdam University Medical Centers
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,750
Awards: G1808489503, G2387717032, G2700626909, New models of radiation endotheliopathy, G4459349314, Identifying Novel Diagnostics and Mechanisms for Cardiac Allograft Vasculopathy, G6434639529, G7249858619, The BYPASS-CTCA Study: A Randomised controlled trial assessing the value of Computed Tomography Cardiac Angiography (CTCA) in reducing procedure duration, limiting post-procedural kidney damage and improving patient satisfaction in patients who had previous bypass operation undergoing invasive coronary angiography (ICA), G9000109956
OpenAlex ID: W3020167520