Pd16-05 the Inverse Correlation Between Obesity and Mortality in Patients With Metastatic Castration Resistant Prostate Cancer: Results From the Control Arms of Ascent2, Mainsal and Venice Trials
Year: 2020
Type: article
Abstract: function, we evaluated the pre-and post-treatment serum brain natriuretic peptide (BNP), which is a marker for left ventricular cardiac load, in prostate cancer patients who received GnRH antagonists or agonists as a neoadjuvant therapy before definitive surgery or radiotherapy.METHODS: We retrospectively identified 86 patients who received GnRH antagonists (n[41) or agonists (n[45) as neoadjuvant therapy and then were followed more than 12 months.BNP measured before and 6 months after ADT were collected and the changes in BNP was assessed using the paired t-test.All CVD events occurred after ADT were recorded and compared between patients receiving GnRH antagonists and agonists.RESULTS: There were no significant differences between two groups in CVD risk-associated parameters including smoking, history of hypertension, hyperlipidemia, diabetes, and CVD, except for that the patients who received GnRH antagonists were significantly older than those received agonists (median 74 vs 65, p<0.01).Pre-existing CVD was present in 4 (10%) of the 41 patients who received antagonists and 6 (13%) of the 45 patients who received agonists.The patients who received GnRH antagonists showed no change in BNP levels, however those who received agonists showed significant increase in BNP (mean change 17.4 pg/ml, 95% CI: 7.5 e 27.2, paired t-test p<0.01, Figure ).CVD events were observed 1 (2%) of the 41 patients who received GnRH antagonists and 2 (4%) of the 45 patients who received agonists, and the incidence of CVD events were not different between these two groups.CONCLUSIONS: GnRH agonists significantly increased BNP in prostate cancer patients while antagonists did not cause significant change.The selection of ADT modality may affect the cardiovascular outcomes.
Source: The Journal of Urology
Institution: Concordia University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3020364836