Mp51-06 Tumor-infiltrating T-cells in Prostate Cancer From Men of African Ancestry (aa) Correlate With Low Androgen Receptor Activity and Increased Metastatic Risk
Year: 2020
Type: article
Abstract: INTRODUCTION AND OBJECTIVE: Current metastatic burden definitions do not account for lymph node metastases (LNM) (location, size or number).Ongoing and planned metastasis directed therapy trials also vary in their LNM inclusion criteria.We report results of a comprehensive analysis of cross-sectional baseline staging scans, including full LNM status, with further linkage to clinical outcome from M1 patients in the STAMPEDE trial.METHODS: 1086 metastatic (M1) pts randomized to Arms A or C in 2:1 ratio between 5 th October 2005 and 31 st March 2013 were eligible for inclusion.Detailed LNM evaluation was performed using Royal College of Radiology lymph node diagnostic criteria for conventional cross-sectional imaging (CT/MRI).Scans were reviewed centrally by two readers (radiologist and urologist).LN number and size were annotated in regional (obturator, external iliac, internal iliac and sacral) and non-regional (common iliac, retroperitoneal, mediastinal) areas.Findings were correlated with clinical outcome after treatment.RESULTS: LNM distribution was evaluable for 629 men (median age 66, median PSA 115 ng/ml): 307 had lymphadenopathy.Of these, 178 had non-regional LNM (median node number 4, median maximum size 2.1 cm (range 1 to 8.1) and minimum size 1.2 cm (range 0.9 to 3.9).Following regional assessment, obturator LN disease was the most common (203 men), followed by internal (133) and external iliac (117) nodes.For non-regional LNM, 87 patients had both common iliac and retroperitoneal LN disease.All data is linked to clinical outcome following treatment, which will be reported.CONCLUSIONS: This analysis of number, size and location LNM defines LN burden in M1 HSPC using standard imaging.The data linked to STAMPEDE trial treatment outcome will help refine existing metastatic burden criteria and treatment decision making in advanced prostate cancer.
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3021062720