Year: 2020
Type: article
Study design: Observational Study
Abstract: PURPOSE: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. METHODS: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. RESULTS: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. CONCLUSION: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased.
Authors: Inés Gómez-Acebo, Trinidad Dierssen-Sotos, Camilo Palazuelos-Calderón, Beatriz Pérez-Gómez, Pilar Amiano, Marcela Guevara, Antonio J. Molina, Laia Domingo, María Fernández-Ortiz, Victor Moreno, Juan Alguacil, Guillermo Fernández-Tardón, Josefa Ibáñez, Rafael Marcos-Gragera, Marian Diaz-Santos, M. Henar Alonso, Jessica Alonso-Molero, Gemma Castaño-Vinyals, Andrés García Palomo, Eva Ardanaz, Amaia Molinuevo, Nuria Aragonés, Manolis Kogevinas, Marina Pollán, Javier Llorca
Institutions: Universidad de Cantabria, Instituto de Investigación Marqués de Valdecilla, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Centro Nacional de Epidemiología, Biogipuzkoa Health Research Institute, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Universidad de León, Municipal Institute for Medical Research, Hospital del Mar Research Institute, Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat de Barcelona, Universidad de Huelva, Instituto de Investigación Sanitaria del Principado de Asturias, Generalitat Valenciana, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Generalitat de Catalunya, Departament de Salut, Universitat Pompeu Fabra, Barcelona Institute for Global Health, Complejo Asistencial Universitario de León
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,860
Awards: G1515769786, G178315305, G1900157527, G2620658983, G2739777946, G2794027481, G3360488230, G3537113396, G3771020718, G3807906117, Identificación de marcadores de susceptibilidad genética útiles para el diseño de estrategias personalizadas de cribado, G4502495630, G4561499809, G4764183276, G5394670091, G5578384164, G5886078521, G6260981759, G6302472787, G6737142931, G6739630186, G7349428362, G7352723158, G8615150659, G8759146715, G8931017233, Perfil molecular del envejecimiento en la patogénesis y pronóstico de la leucemia linfática crónica
OpenAlex ID: W3021089505