Mp10-03 Association Between Low-testosterone and Kidney Stones in Us Men: Analysis of the National Health and Nutrition Examination Survey
Year: 2020
Type: article
Abstract: You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology II (MP10)1 Apr 2020MP10-03 ASSOCIATION BETWEEN LOW-TESTOSTERONE AND KIDNEY STONES IN US MEN: ANALYSIS OF THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY Jonathon Katz*, Sirpi Nackeeran, Ranjith Ramasamy, and Robert Marcovich Jonathon Katz*Jonathon Katz* More articles by this author , Sirpi NackeeranSirpi Nackeeran More articles by this author , Ranjith RamasamyRanjith Ramasamy More articles by this author , and Robert MarcovichRobert Marcovich More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000830.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Increasing age, male gender, and metabolic syndrome are associated with kidney stone formation. As sex hormones change with age, gender and metabolic syndrome, we hypothesized that sex hormones underlie the physiologic changes affecting stone formation because of the gender disparity seen with renal stones (males >> females). METHODS: Using the National Health and Nutrition Survey (NHANES) results from 2013-2016, we performed a cross-sectional nested case-control study using data on 3767 male participants and 3994 female participants. We performed a logistic regression analysis to analyze the predictive value of low testosterone on history of kidney stone, controlling for age and BMI in both males and females. For males, low testosterone was defined as Low (< 300 ng/dL) or Normal (> 300 ng/dL), in females Low Testosterone (< 10 ng/dL) or Normal (>10 ng/dL). Estrogen in males was defined as Low (<10 pg/mL) or normal (> 10 pg/mL) and in females was categorically defined as Low (< 10 pg/mL) or Normal (> 10 pg/mL). Additionally, age (years), and BMI in (Kg/M^2) were investigated. Self-reported history of kidney stone diagnosis was the outcome. RESULTS: Using logistic regression adjusting for age and BMI, low testosterone was independently associated with a history of kidney stones in males (OR=1.392, 95% CI: 1.101-1.759). There was no significant association between estrogen and stone formation in males. Neither estrogen nor testosterone were significantly associated with stone formation in Females. Strengths include this being the first study to report association between testosterone levels and renal stone prevalence in a contemporary cohort. Limitations of our study include the possible presence of confounding factors such as environmental influences and diabetes on serum testosterone as well as sampling bias due to incomplete response rates. CONCLUSIONS: Low testosterone is associated with kidney stones in men. Whether this association reflects a common causal pathway or shared risk factors such as metabolic syndrome requires additional investigation. Further studies matching menopausal status for women are necessary to investigate the relationship between estrogen and protection against kidney stones. Source of Funding: None. © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e126-e126 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jonathon Katz* More articles by this author Sirpi Nackeeran More articles by this author Ranjith Ramasamy More articles by this author Robert Marcovich More articles by this author Expand All Advertisement PDF downloadLoading ...
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3021096126