Work

Chimeric-Antigen-Receptor (CAR) T Cells and the Factors Influencing their Therapeutic Efficacy.

Year: 2017

Type: article

Abstract: culture system, target selection, and preconditioning regimens. While recent clinical trials have shown promising success, cytotoxicity and other various challenges need to be addressed before CAR therapy can reach its full clinical potency. This review will discuss factors associated with CAR therapeutic success and the difficulties that continue to be a focus of research around the world.

Source: PubMed

Authors: Victoria G Kravets, Yi Zhang, Hongxing Sun

Institutions: Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering, Temple University

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute

Awards: Delta-like ligand 4+ dendritic cells and induction of alloimmunity, Antigen Presenting Cells in the Induction of GVHD, Ezh2-mediated Epigenetic Effects and Alloimmunity