Work

Reactive Oxygen Species in HIV Infection.

Year: 2016

Type: article

Abstract: Reactive oxygen species (ROS) are a family of oxygen molecules with an unpaired electron and play an important role in homeostasis and pathogenesis. The reactive molecules modify lipids, proteins and nucleic acids, and modulate a wide range of cellular functions. The importance of ROS in infection has been established through clinical and in vitro studies. Here we review the role of oxidative stress in HIV pathogenesis, the impact of ROS on immune responses in HIV patients, and ROS-mediated regulation of HIV infection. Future studies on the interplay between ROS and HIV infection may offer a new strategy for prevention and treatment.

Source: PubMed

Authors: Jennifer Couret, Theresa L Chang

Institutions: Rutgers, The State University of New Jersey, Rutgers New Jersey Medical School

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Award: Modulation of innate immunity,microbiome and HIV transmission by Depo-Provera