Work

Agomelatine protects against myocardial ischemia reperfusion injury by inhibiting mitochondrial permeability transition pore opening.

Year: 2018

Type: article

Abstract: , indicating inhibition of mitochondrial permeability transition pore (MPTP) opening. Notably, agomelatine's protective effects were abrogated by atractyloside, a MPTP opener. We also found that agomelatine significantly enhanced GSK-3β phosphorylation and decreased expression of cytochrome C, cleaved caspase 9 and cleaved caspase 3, resulting in a decreased apoptosis rate. These findings demonstrate that agomelatine protects against MIRI by inhibiting MPTP opening.

Source: Europe PMC (PubMed Central)

Authors: Pengyu Jia, Chunting Liu, Nan Wu, Dalin Jia, Yingxian Sun

Institution: First Hospital of China Medical University

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3021500411

FWCI: 3.591

Cites: 42

Cited by: 31

Related to: 10