Work

Discoidin domain receptor 1 activity drives an aggressive phenotype in bladder cancer.

Year: 2017

Type: article

Abstract: tumor xenograft growth could be promoted by the overexpressed DDR1, while both of which could be inhibited after the depletion of DDR1. Furthermore, DDR1 increased the levels of ZEB1 and Slug, based on its effects on tumor invasion. In conclusion, DDR1 may promote the aggressiveness of bladder cancer cells and drive an aggressive phenotype in bladder cancer.

Source: Europe PMC (PubMed Central)

Authors: Xin Xie, Wenbin Rui, Wei He, Yuan Shao, Fukang Sun, Wenlong Zhou, Yuxuan Wu, Yu Zhu

Institutions: Shanghai Jiao Tong University, Ruijin Hospital

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3021617246

FWCI: 2.777

Cites: 36

Cited by: 20

Related to: 10