Work

Effects of long non-coding RNA SPRY4-IT1 on osteosarcoma cell biological behavior.

Year: 2016

Type: article

Abstract: . Our result showed that SPRY4-IT1 was upregulated in OS tissues. Further experiments revealed that SPRY4-IT1 knockdown significantly inhibited OS cells proliferation by causing G1 arrest and promoting apoptosis. Furthermore, inhibitory effects of SPRY4-IT1 on cell migration and invasion were partly associated with EMT process. In conclusion, these data suggest that SPRY4-IT1 could be an oncogene for OS, and may be served as a candidate target for new therapies in human OS.

Source: PubMed

Authors: Jin Xu, Ren Ding, Yaozeng Xu

Institution: First Affiliated Hospital of Soochow University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3021637440

FWCI: 1.057

Cites: 22

Cited by: 18

Related to: 10