Year: 2020
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Biomarker discovery of dementia and cognitive impairment is important to gather insight into mechanisms underlying the pathogenesis of these conditions. METHODS: In 997 adults from the InCHIANTI study, we assessed the association of 1301 plasma proteins with dementia and cognitive impairment. Validation was conducted in two Alzheimer's disease (AD) case-control studies as well as endophenotypes of AD including cognitive decline, brain amyloid burden, and brain volume. RESULTS: We identified four risk proteins that were significantly associated with increased odds (peptidase inhibitor 3 (PI3), trefoil factor 3 (TFF3), pregnancy associated plasma protein A (PAPPA), agouti-related peptide (AGRP)) and two protective proteins (myostatin (MSTN), integrin aVb5 (ITGAV/ITGB5)) with decreased odds of baseline cognitive impairment or dementia. Of these, four proteins (MSTN, PI3, TFF3, PAPPA) were associated cognitive decline in subjects that were cognitively normal at baseline. ITGAV/ITGB5 was associated with lower brain amyloid burden, MSTN and ITGAV/ITGB5 were associated with larger brain volume and slower brain atrophy, and PI3, PAPPA, and AGRP were associated with smaller brain volume and/or faster brain atrophy. DISCUSSION: These proteins may be useful as non-invasive biomarkers of dementia and cognitive impairment.
DOI: 10.1002/trc2.12018
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,200
Awards: G1090328858, G1248102086, G1282666458, G1789381357, G2243371366, G2495888254, G249615658, G259853090, G2857511458, G3117239229, G3303013554, G3362311673, G374919288, G4109153585, G4507648799, G4652745033, Risk Factors, Pathology, and Clinical Expressions of AD, G4940211717, G5038676132, G6145130349, G7333524540, G828200374, HISPANIC SECONDARY STROKE PREVENTION INITIATIVE, Johns Hopkins Alzheimer's Disease Research Center, G93682057, G983864884
OpenAlex ID: W3022017154