Work

Evaluating Changes in Immune Function and Bone Microenvironment During Radium-223 Treatment of Patients with Castration-Resistant Prostate Cancer

Year: 2020

Type: article

Abstract: The effects of radium-223 on the immune system and the bone tumor microenvironment are incompletely understood. The authors describe mechanisms by which radium-223 may interact with the immune system, specifically through STAT-3 and impact on tumor and circulating lymphocyte populations. They review mechanisms through which effects of radium-223 and androgen-targeted therapy on bone microenvironment could be better elucidated. These knowledge gaps currently limit development of optimal combination therapy approaches for radium-223. Tissue based studies are currently underway in a prospective clinical trial to enhance therapeutic perspective on radium-223 treatment in the prostate cancer landscape.

Source: Cancer Biotherapy and Radiopharmaceuticals

DOI: 10.1089/cbr.2019.3397

Authors: Tanya B. Dorff, Cy Stein, Marcin Kortylewski, Edwin Posadas, Timothy Synold, David Quinn