Work

Periodontal disease and cancer: Epidemiologic studies and possible mechanisms

Year: 2020

Type: review

Abstract: Epidemiologic and cancer control studies on the association of periodontal disease and cancer risk mostly suggest a positive association with overall cancer risk and certain specific types of cancer. These findings are generally consistent among cross-sectional and longitudinal studies. In this paper, we review epidemiologic studies and current knowledge on periodontal disease and cancer, with a focus on those studies conducted in the years following the Joint European Federation of Periodontology/American Academy of Periodontology Workshop on "Periodontitis and Systemic Diseases" in November 2012. This review also explores the role of chronic inflammation as a biologically plausible mechanistic link between periodontal disease and risk of cancer. Furthermore, it highlights studies that have examined the potential importance of certain periodontal pathogens in this association.

Source: Periodontology 2000

DOI: 10.1111/prd.12329

Authors: Ngozi Nwizu, Jean Wactawski‐Wende, Robert J. Genco

Institutions: Roswell Park Comprehensive Cancer Center, University at Buffalo, State University of New York, The University of Texas Health Science Center at Houston

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,000