Work

TLR4-dependent internalization of CX3CR1 aggravates sepsis-induced immunoparalysis.

Year: 2016

Type: article

Abstract: or TLR4 inhibitor-treated macrophages exhibited an inhibited expression of GRK2 and β-arrestin2, along with reduced internalization of CX3CR1. Moreover, the knockdown of GRK2 and β-arrestin2 inhibited the internalization of CX3CR1 and led to a higher response on the second hit, which was associated with an increased activation of NF-κB. The critical association between internalization of CX3CR1 and immunosuppression in sepsis may provide a novel reference for clinical therapeutics.

Source: PubMed

Authors: Xin-Yu Ge, Shang-Ping Fang, Miao Zhou, Jing Luo, Juan Wei, Xue-Ping Wen, Xiao-Di Yan, Zui Zou

Institutions: Hebei North University, Second Military Medical University, Shanghai Changzheng Hospital, Shanghai Jiao Tong University, XinHua Hospital, Tongji University, Xuzhou Medical College, Shanghai Pulmonary Hospital, Jiangsu Province Key Laboratory of Anesthesiology, Soochow University

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3022507463

FWCI: 0.483

Cites: 46

Cited by: 17

Related to: 10