Work

Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

Year: 2020

Type: article

Source: Molecular Cancer Research

DOI: 10.1158/1541-7786.mcr-20-0024

Authors: Mio Harachi, Kenta Masui, Hiroaki Honda, Yoshihiro Muragaki, Takakazu Kawamata, Webster K. Cavenee, Paul S. Mischel, Noriyuki Shibata

Institutions: Tokyo Women's Medical University, University of California San Diego

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Institutes of Health, Japan Society for the Promotion of Science, National Institute of Neurological Disorders and Stroke

Awards: Functional analyses of enzymatic activity- and complex formation-dependent roles of UTX in the regulation of hematopoietic stem cells and development of hematopoietic diseases, mTOR-dependent hypomethylator phenotype in glioblastoma, Elucidation of mechanisms underlying stem cell aging induced by deregulation of histone modifications and development of anti-aging therapies by maintaining their functions, The role of mTORC2 in reprogramming cancer cell metabolism

OpenAlex ID: W3022771815

FWCI: 1.313

Cites: 52

Cited by: 51

Related to: 10