Work

Role of Notch signaling pathway in pancreatic cancer.

Year: 2017

Type: article

Abstract: Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United States. It has been shown that multiple signaling pathways are involved in the pathogenesis of PC, such as JNK, PI3K/AKT, Rho GTPase, Hedgehog (Hh) and Skp2. In recent years, accumulated evidence has demonstrated that Notch signaling pathway plays critical roles in the development and progression of PC. Therefore, in this review we discuss the recent literature regarding the function and regulation of Notch in the pathogenesis of PC. Moreover, we describe that Notch signaling pathway could be down-regulated by its inhibitors or natural compounds, which could be a novel approach for the treatment of PC patients.

Source: Europe PMC (PubMed Central)

Authors: Jiankun Gao, Bo Long, Zhiwei Wang

Institutions: Sichuan College of Traditional Chinese Medicine, Sichuan Mianyang 404 Hospital, Beth Israel Deaconess Medical Center, Soochow University, First Affiliated Hospital of Soochow University

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3022943160

FWCI: 4.189

Cites: 147

Cited by: 72

Related to: 10