The neurocognitive correlates of brain entropy estimated by resting state fMRI
Year: 2021
Type: article
Abstract: Resting state brain activity consumes most of brain energy, likely creating and maintaining a reserve of general brain functionality. The latent reserve if it exists may be reflected by the profound long-range fluctuations of resting brain activity. The long-range temporal coherence (LRTC) can be characterized by resting state fMRI (rsfMRI)-based brain entropy (BEN) mapping. While BEN mapping results have shown sensitivity to neuromodulations or disease conditions, the underlying neuromechanisms especially the associations of BEN or LRTC to neurocognition still remain unclear. To address this standing question and to test a novel hypothesis that resting BEN reflects a latent functional reserve through the link to general functionality, we mapped resting BEN of 862 young adults and comprehensively examined its associations to neurocognitions using data from the Human Connectome Project (HCP). Our results unanimously highlighted two brain circuits: the default mode network (DMN) and executive control network (ECN) through their negative associations of BEN to general functionality, which is independent of age and sex. While BEN in DMN/ECN increases with age, it decreases with education years. These results demonstrated the neurocognitive correlates of resting BEN in DMN/ECN and suggest resting BEN in DMN/ECN as a potential proxy of the latent functional reserve that facilitates general brain functionality and may be enhanced by education.
Source: NeuroImage
Author: Ze Wang
Institution: University of Maryland, Baltimore
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,300
Funders: Washington University in St. Louis, National Institutes of Health, Institute for Clinical and Translational Research, University of Wisconsin, Madison, McDonnell Center for Systems Neuroscience, National Institute on Aging, National Institute of Mental Health, NIH Blueprint for Neuroscience Research, National Center for Advancing Translational Sciences
Awards: Brain entropy mapping in Alzheimer's Disease, Mapping the Human Connectome: Structure, Function, and Heritability, G3848525072, Assessing ASL CBF as a biomarker for early Alzheimer's disease detection and disease progression, Johns Hopkins Institute for Clinical and Translational Research, G7957290912
OpenAlex ID: W3023013569