Work

p38 MAPK signaling is a key mediator for low-intensity pulsed ultrasound (LIPUS) in cultured human omental adipose-derived mesenchymal stem cells.

Year: 2019

Type: article

Abstract: ) increased hAMSC viability. Phosphorylation of p38, a mitogen-activated protein kinase (MAPK), increased with high dose LIPUS treatment, but markedly decreased with a low dose. Inhibition of p38 phosphorylation by SB203580, an inhibitor of p38 MAPK activity, rescued the apoptotic effects of high dose LIPUS. Our results showed the dose-dependent, opposing effects of LIPUS on hAMSCs and suggested that p38 plays a key role in mediating the effects of LIPUS on hAMSCs.

Source: Europe PMC (PubMed Central)

Authors: Yaqing Wang, Li Jiang, Tianhua Xu, Zhongping Su, Xiasheng Guo, Juan Tu, Dong Zhang, Wei Sun, Xiangqing Kong

Institutions: Jiangsu Province Hospital, Collaborative Innovation Center of Advanced Microstructures, Nanjing University

Language: English

Topic: Mesenchymal stem cell research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3023113995

FWCI: 0.722

Cites: 34

Cited by: 12

Related to: 10