Work

Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives

Year: 2012

Type: article

Abstract: A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also demonstrated.

Source: Organic Letters

DOI: 10.1021/ol301700y

Authors: Meredeth A. McGowan, Camille Z. McAvoy, Stephen L. Buchwald

Institution: Massachusetts Institute of Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G1347613584, Development of a Palladium-Catalyzed Direct N2-Arylation of Indazoles., CATALYTIC METHODS FOR ORGANIC SYNTHESIS, Late Transition Metal Catalysts for Organic Synthesis