Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues
Year: 2020
Type: article
Abstract: In this work, we present a novel bioreactor that allows for active length control of engineered heart tissues during extended tissue culture. Specific length transients were designed so that engineered heart tissues generated complete cardiac work loops. Chronic culture with various work loops suggests that mitochondrial mass and biogenesis are directly regulated by work output.
Institution: Yale University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, Paul and Daisy Soros Fellowships for New Americans, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Advancing Translational Sciences
Awards: Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy, Institutional National Research Service Award, Medical Scientist Training Program, Investigating Polycystin-2 up-regulation as a stress response through its role in non-alcoholic fatty liver disease, CAREER: A Systems Approach to Discovering Mechanical Sensors in Heart Muscle Cells, Dual-specificity phosphatase action in muscle disease, Yale Clinical and Translational Science Award
OpenAlex ID: W3023190019