Work

Repurposing Fenamic Acid Drugs To Combat Multidrug-Resistant Neisseria gonorrhoeae

Year: 2020

Type: article

Abstract: The rise of extensively drug-resistant and multidrug-resistant strains of Neisseria gonorrhoeae has occurred in parallel with the increasing demand for new drugs. However, the current methods of drug discovery are burdened with rigorous assessments and require more time than can be spared until gonococcal infections become difficult to control. To address this urgency, we utilized a drug-repurposing strategy and identified three clinically approved anthranilic acid drugs (tolfenamic acid, flufenamic acid, and meclofenamic acid) with potent antigonococcal activity, inhibiting 50% of the strains (MIC 50 ) from 4 to 16 μg/ml.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02206-19

Authors: Young Jin Seong, Marwa Alhashimi, Abdelrahman Mayhoub, Haroon Mohammad, Mohamed N. Seleem

Institutions: Purdue University West Lafayette, Al-Azhar University, Zewail City of Science and Technology

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3023266079

FWCI: 1.489

Cites: 47

Cited by: 37

Related to: 10