Year: 2020
Type: review
Abstract: In this review, we discuss the growing literature demonstrating robust and pervasive associations between the microbiome and metabolome. We focus on the gut microbiome, which harbors the taxonomically most diverse and the largest collection of microorganisms in the human body. Methods for integrative analysis of these "omics" are under active investigation and we discuss the advances and challenges in the combined use of metabolomics and microbiome data. Findings from large consortia, including the Human Microbiome Project and Metagenomics of the Human Intestinal Tract (MetaHIT) and others demonstrate the impact of microbiome-metabolome interactions on human health. Mechanisms whereby the microbes residing in the human body interact with metabolites to impact disease risk are beginning to be elucidated, and discoveries in this area will likely be harnessed to develop preventive and treatment strategies for complex diseases.
Source: Metabolites
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,690
Awards: Multi-omic approaches to mechanisms of vitamin D, environmental influences, and the microbiome on asthma, Mechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomics, Integrative Metabolomics of Asthma Severity, Multi-Omics Analysis of the Association of Polyunsaturated Fatty Acids with Asthma and Allergy in Childhood, Multi-Omic Endotyping of Asthma, Metabolomics from a Controlled Feeding Study and Large Cohorts to Identify Diet-Associated Biomarkers, Augmented by Genetics to Infer Causality for Cardiometabolic Outcomes, Environmental Agents as Modulators of Disease Processes, Omic Determinants of Longitudinal Lung Function in Asthma
OpenAlex ID: W3023514173