Mp72-05 Correlation Between Bmi and Outcomes in Patients Treated With Bcg Immunotherapy for Non-muscle Invasive Bladder Cancer
Year: 2020
Type: article
Abstract: You have accessJournal of UrologyBladder Cancer: Non-invasive III (MP72)1 Apr 2020MP72-05 CORRELATION BETWEEN BMI AND OUTCOMES IN PATIENTS TREATED WITH BCG IMMUNOTHERAPY FOR NON-MUSCLE INVASIVE BLADDER CANCER Nathan Brooks*, Justin Matulay, Lianchun Xiao, Roger Li, Andrea Kokorovic, H. Barton Grossman, Yu Shen, Jianjun Gao, Neema Navai, Colin Dinney, and Ashish Kamat Nathan Brooks*Nathan Brooks* More articles by this author , Justin MatulayJustin Matulay More articles by this author , Lianchun XiaoLianchun Xiao More articles by this author , Roger LiRoger Li More articles by this author , Andrea KokorovicAndrea Kokorovic More articles by this author , H. Barton GrossmanH. Barton Grossman More articles by this author , Yu ShenYu Shen More articles by this author , Jianjun GaoJianjun Gao More articles by this author , Neema NavaiNeema Navai More articles by this author , Colin DinneyColin Dinney More articles by this author , and Ashish KamatAshish Kamat More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000952.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The association of body mass index (BMI) with clinical outcomes for patients with solid malignancies receiving immune checkpoint (ICI) therapy has demonstrated improvement for overweight and obese patients. Given the paucity of the available data on BMI and clinical outcomes in patients with non-muscle invasive bladder cancer (NMIBC) treated with BCG, we explored this relationship in 582 patients who completed an induction course of BCG. METHODS: All NMIBC patients treated with an induction course of BCG (minimum 5/6 planned instillations) from 2006 to 2018 were reviewed. BMI was calculated at the initial clinic visit. Kaplan-Meier (KM) estimates with log-rank test were used to analyze recurrence free (RFS), progression free (PRS), cancer specific (CSS) and overall (OS) survival. A p-value ≤0.05 was considered significant. Progression was development of muscle invasive bladder cancer or metastasis. Survival was timed from the start of BCG. RESULTS: The mean age of 582 patients was 67. 89% of patients were high grade and 95% of patients received additional BCG after induction. 24% of patients were normal or underweight (<1% of patients were underweight). 76% of patients were obese (51%) or overweight (49%). With a median of 56 months follow-up, recurrence occurred in 35% of patients, progression occurred in 10% of patients and 15% of patients underwent cystectomy. Overall 10 yr CSS and OS were 93% and 63%, respectively; BMI ≥25 was significantly associated with higher PFS (10 yr: 64% vs 43%), CSS (10 yr: 96% vs 86%) and OS (10 yr: 68% vs 49%) (Figure). The effect was maintained on multivariate analysis (Table). CONCLUSIONS: In this contemporary cohort of patients, overweight and obese patients exhibited significantly improved OS, CSS, and PFS when receiving BCG therapy. These findings recapitulate those seen in melanoma with ICI and present an opportunity for efforts in translational research to identify the underlying biologic driver of this interaction. Source of Funding: Duddlesten Professorship Floyd Research Account © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1075-e1075 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Nathan Brooks* More articles by this author Justin Matulay More articles by this author Lianchun Xiao More articles by this author Roger Li More articles by this author Andrea Kokorovic More articles by this author H. Barton Grossman More articles by this author Yu Shen More articles by this author Jianjun Gao More articles by this author Neema Navai More articles by this author Colin Dinney More articles by this author Ashish Kamat More articles by this author Expand All Advertisement PDF downloadLoading ...
Source: The Journal of Urology
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3023525798