Work

Decreased vitamin D receptor protein expression is associated with progression and poor prognosis of colorectal cancer patients.

Year: 2020

Type: article

Abstract: ) and generated moderate diagnostic performance for CRC detection (AUC = 0.88, sensitivity = 0.87, specificity = 0.84). Low VDR expression was associated with invasion depth (P = 0.001) and poor survival in CRC (P = 0.031). Univariate Cox analysis demonstrated VDR expression (P = 0.036) was a significant prognostic predictor for survival in patients with CRC. Low VDR expression could be a valuable diagnostic and prognostic biomarker for CRC patients. Targeting VDR may offer a potential therapeutic strategy for blocking CRC.

Source: PubMed Central

Authors: Qi Shi, Xue-Ping Han, Jie Yu, Hao Peng, Yun-Zhao Chen, Feng Li, Xiao-Bin Cui

Institutions: Shihezi University, First Affiliated Hospital of Shihezi University Medical College, Capital Medical University, Beijing Chao-Yang Hospital, Capital Medical University

Language: English

Topic: Vitamin D Research Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3023760587

FWCI: 1.68

Cites: 30

Cited by: 11

Related to: 10