Development and validation of strategies to mitigate the risk of hypoglycemic events in type 1 diabetes mellitus
Year: 2019
Type: dissertation
Abstract: Type 1 diabetes mellitus (T1DM) is a chronic condition resulting from the destruction of insulin-producing pancreatic beta-cells due to an autoimmune process that may occur at any age, but tends to develop in childhood and adolescence. T1DM results in an impairment of insulin secretion by the pancreas. Therefore, individuals afflicted with T1DM require an uninterrupted supply of exogenous insulin to survive. If insulin is not provided, subjects can face several complications associated with the damage and failure of various organ systems. In this work, different strategies were evaluated to reduce the risk of hypoglycemia, which is the most feared situation by patients. The strategies are: 1) A new methodology to adjust the upper limit of IOB of the controller, 2) Development of mitigation strategies for aerobic exercise, 3) Prediction of nocturnal hypoglycemia for patients under MDI therapy using machine learning algorithms.
Author: Arthur Bertachi
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G216720077, G5905040377
OpenAlex ID: W3023847732