Work

Homology-directed repair involves multiple strand invasion cycles in fission yeast

Year: 2022

Type: article

Abstract: A live-cell assay is developed to monitor interhomologue repair of a DNA double-strand break in Schizosaccharomyces pombe, revealing that multiple cycles of homology search and strand invasion occur during repair. It is proposed that these dynamics reflect a preference for repair by synthesis-dependent strand annealing in fission yeast.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.e20-07-0433

Authors: Amanda J. Vines, Kenneth Cox, Bryan A. Leland, Megan C. King

Institution: Yale University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences

Awards: Predoctoral Program in Cellular and Molecular Biology, Cancer Center Support Grant