Work

Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome

Year: 2020

Type: article

Abstract: Significance To examine the function of KBTBD2 in different cell types, we knocked the gene out in adipocytes, liver, and muscle cells. None of these conditional knockouts could reproduce the growth retardation observed in mice with a global knockout. An adipose tissue-specific knockout was similar to a global knockout in most respects; however, hyperglycemia was less severe and hyperinsulinemia was more sustained. An adipose tissue-specific knockout caused insulin resistance in other tissues, demonstrating an adipose-extrinsic effect of the mutation.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2000118117

Authors: Zhao Zhang, Thomas Gallagher, Philipp E. Scherer, Bruce Beutler

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Adipose Tissue and Metabolism

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid